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[55] conducted an experiment using amifostine (a radioprotector currently available in clinical practice) 30 min prior to a lethal whole abdominal dose radiation in SpragueDawley rats

What Makes Periorbital Skin So Vulnerable A 2019 clinical assessment published in Clinical, Cosmetic and Investigational Dermatology confirmed that under-eye dark circles correlate with measurably thinner skin, higher hemoglobin index (a marker of vascular prominence), and a higher melanin index all pointing to both vascular and pigmentary contributors rather than just one single cause

doi: 10.21037/atm-21-2514

PMID: 6 CaioGVoltaUSaponeALefflerDADe GiorgioRCatassiCet al

Increased levels of lignin helps to fix the cell wall and represents a detoxification mechanism induced by heavy metal stress over long-term evolution in plants [62]