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Other documented ozone-induced effects that may be related to the underlying injury and inflammatory response are: An increase in small airway obstruction A decrease in the integrity of the airway epithelium An increase in nonspecific airway reactivity A decrease in phagocytic activity of alveolar macrophages The decrease in epithelial integrity can be measured by an increase in the concentration of plasma proteins appearing in the ELF following exposure and by more rapid clearance of inhaled radio-labeled markers from the lung to the blood

The use of NHBDs as a source of liver grafts for transplantation has long been debated

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Huang J, Dorsey J, Chuikov S, Perez-Burgos L, Zhang X, Jenuwein T et al

However, high doses may cause excessive bleeding and oxidative stress