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Metabolites that significantly correlated with PROMIS-Fatigue T -scores were overrepresented by the steroid hormone biosynthesis pathway (KEGG ID: M00107), including androgen and estrogen metabolism (SMPDB ID: SMP0000068) and androstenedione metabolism (SMPDB ID: SMP0030406) (Figure 4C), which included androsterone sulfate ( r = 0.26, p = 0.0009), epiandrosterone sulfate ( r = 0.25, p = 0.0016), etiocholanolone glucuronide ( r = 0.19, p = 0.018), and dehydroepiandrosterone sulfate (DHEA-S) ( r = 0.18, p = 0.023)

These microorganisms are crucial for digesting nutrients, metabolizing energy, glucose, and cholesterol, and modulating chronic inflammation, significantly affecting the interplay between diet, obesity, and related diseases (101, 102)

Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor

Increased fat-burning potential: Men have faster metabolisms, so they can burn fat faster, especially when exercising, which may help them lose more fat overall

They can be accompanied by other foods like fruits or cereals and can also be eaten alone