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In ALS patients and rodent models, EAAT2 expression is reduced in astrocytes in the motor cortex and spinal cord, which could cause an accumulation of excitotoxic levels of extracellular glutamate and subsequently increase the neuronal intracellular calcium concentration and initiate cascades that regulate motor neuron death ([99103]

Gut microbiota metabolites 1,3-diaminopropane and reuterin were considered key factors in reducing iron absorption by suppressing HIF-2 activity and upregulating the iron-storage protein ferritin, thereby alleviating systemic iron overload [162]

doi: 10.1016/j.phrs.2022.106550 78 KoppulaP.ZhuangL.GanB

The combination creates a multi-pathway research model