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Kaur J, Manju, Kaur A, Yadav M, Raina N, Kumar S, Kumar A, Gupta M

Therefore, LPS not only primes the inflammasome by upregulating IL-1 transcriptionally but also triggers post-translational K63-ubiquitin, K48-ubiquitin, and K11-ubiquitin chain modification of IL-1 that correlate with its proteasomal degradation at a rate comparable to other short-lived proteins, such as Mcl-1 25