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Description

Anti-atherosclerotic activity of root bark of Premna integrifolia Linn

PMID 10657232

(Peptide Sciences) Comparative advantage and specificity Researchers note that many senolytics suffer from off-target cytotoxicity (i.e., they kill healthy cells too)

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Quercetin also inhibits the expression of -SMA, a marker of HSCs activation, reduces protein levels of desmin and vimentin, downregulates macrophage markers F4/80 and CD68, decreases mRNA expression of TNF-, IL-1, IL-6, and MCP-1, and reduces macrophage recruitment