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Although there is no reason to believe that a neutral antagonist would directly affect MC3R signaling, the possibility remains that such an antagonist may lead to cross-sensitization or reduced internalization of the dimer, in effect amplifying MC3R signaling further through increased surface expression or sensitization

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doi: 10.1016/j.bbamcr.2012.05.010 42 NadimpalliHPKatsioudiGArpaESChikhaouiLArpatABLiechtiAet al

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