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Emergency dermatology Medicine

Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47(phox)

Hence, it was postulated that the brain drives these psychiatric comorbidities seen in IBS patients, which leads to the conclusion that IBS is a primary brain disorder or somatic symptom disorder whereby the brain is involved in manifesting the gastrointestinal symptoms (Tanaka et al., 2011

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Front Physiol 8:691 Samra K, Singer M, Dyson A (2019) Hydrogen selenide as the 4th gasotransmitter: a metabolic modulator with potential therapeutic utility in acute/critical illness states