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There is reasonable scientific basis to expect that the GLP-1 component will confer similar cardiovascular protection

Various metabolic parameters, including body composition, liver function, lipid and glucose metabolism, were measured

An important challenge for future studies will be to define which nodes within this multilayered GSH-centered defense network represent true therapeutic vulnerabilities across different tissue and tumor contexts

While peptides are generally less immunogenic than larger proteins, they can still trigger antibody formation in some patients

Academic and industrial efforts have progressively advanced from single-tissue to multi-tissue and multi-organ OoC systems, converging toward autologous OoC (aOoC) platforms that can (i) capture patient-specific immunopathophysiology with higher fidelity, (ii) potentially complement and, in specific contexts, reduce reliance on animal models, and (iii) directly inform immunotherapy development and therapeutic decision-making within precision medicine