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[75] examined T cell metabolism in 53 ME/CFS patients in comparison with 45 healthy controls by isolating CD4 + and CD8 + T cells

Mechanistically, EC inhibited the phosphorylation of NF-B p65, leading to reduced expression of its active form (p-p65), thereby attenuating the inflammatory response (Wu et al., 2022)

10.1667/0033-7587(2002)158[0125:Br]2.0.Co;2 307 WolcottR

Although it is beyond the scope of this study, future research is needed to explore specific changes in sleep patterns caused by reduced androgen metabolites using more precise tools for measuring sleep, such as polysomnography and/or actigraphy