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intramuscular route: count injections given Visit 3 (week 26) Anamnesis: record lifestyle habits and use of alcohol Symptoms: if pathological at the first visit, record paresthesia, asthenia, loss or reduction of appetite, sadness or change in level of happiness, and concomitant pharmacological treatment Physical examination: if pathological at the first visit examine for Hunters glositis, positional and vibrational sensitivity Record concomitant treatment Request analyses to be performed one week before next visit: haemogram and serum vitamin B12 Questionnaire: EuroQoL-5D Assessment of adverse effects Therapeutic plan: patient in oral arm provision of medication

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Ideal for hyperpigmentation, melasma, acne scars, and sun-induced discoloration, this 30g cream delivers targeted brightening while keeping skin moisturised and protected from oxidative stress

In mice models, the doses used were between 100 and 600 mg kg -1 , whereas in rats, they ranged from 0.05 to 10 g kg -1

Cory Mellon, MD Last reviewed June 2026