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Apoptosis, characterized by chromatin condensation, fragmentation and internucleosomal DNA cleavage, and necrosis, characterized by rupture or fragmentation of the plasma membrane and ATP depletion [32] can coexist and share common pathways, such as involvement of the mitochondria [33]

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This decline is closely correlated with the loss of tissue regenerative capacity, increased inflammation, and accelerated skin aging

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In contrast, pharmacological treatment modalities have not advanced significantly over the past 30 years, relying primarily on drugs that alter urinary chemicals to reduce crystalline salt supersaturation

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