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Additionally, the respiratory exchange ratio (RER), food intake, and locomotor activity remained comparable between HFD-fed Ssu72 WT and aKO groups (Supplementary Fig

& Valle, D.) (McGraw-Hill, New York, USA, 2005)

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The microbial translocation through the disrupted tight junctions of GI cells promotes systemic inflammation and can alter the BBB or cause other direct CNS effects via the Vagus nerve