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Furthermore, a functional lactic acid/HIF/2- c-myc signalling pathway has been identified in tumor cells, and lactic acid in the in vitro environment not only was able to stabilize HIF-2 but also activated c-myc [121]

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h , Strand-specificity index (SSI) scatterplots derived from TCR-seq signals of allexpressed genes in control or INTS12 KO cells after mock or UV treatment, followed by recovery for the indicated times

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Consistent with inefficient conversion of pyruvate to acetyl-CoA, there was a clear trend for elevated m+3 lactic acid in the liver of Cse / mice (Extended Data Fig