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Chen F, Xing Y, Chen Z, Chen X, Li J, Gong S, et al

In immature animals, IGF1 can activate the brain-gonadal axis and contributes to the timing of puberty in males and females by affecting GnRH neurons and possibly kisspeptin neurons in the hypothalamus [18]

Proc Natl Acad Sci 101:20402045 Wang H, Liu K, Geng M, Gao P, Wu X, Hai Y, Li Y, Li Y, Luo L, Hayes JD, Wang XJ, Tang X (2013) Rxr inhibits the nrf2-are signaling pathway through a direct interaction with the neh7 domain of nrf2