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With 476,857 individuals across 18 different countries (propensity score matched 1:1 with pregnant controls), this is the largest study to date in this historically underserved population

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95 Another randomized controlled trial that included 88 participants with moderate-to-severe menopausal symptoms found 1,000 mg fenugreek extract daily for 90 days improved hot flashes and other symptoms, as well as quality of life, and increased E2 levels compared with placebo

Collectively, these clinical experiences highlight a key translational challenge: even when therapeutic targets are biologically validated, inefficient CNS delivery limits treatment efficacy while increasing systemic burden