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Pauletti C, Mannarelli D, Locuratolo N, Curr A, Marinelli L, Fattapposta F

Liu et al., 2015

Of note, the formation of lysine-derived, covalent pyridinoline (PYR) cross-links relies on the enzyme LOX, which is hypoxia-response element-directed upregulation during HIF1-transcriptional activation (van Vlimmeren et al., 2010