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The increased presence of pro-inflammatory cytokines, along with elevated levels of HIF-1, stimulates the synthesis of pro-angiogenic factors such as VEGF, EGF, IL-1, IL-8, CCL-28, and CCL-21 by macrophages, T cells, and FLSs within the RA joint

Furthermore, serum BR levels were positively correlated with UPDRS III scores, correlating with improved motor outcomes ( Table 1 Summary of clinical trial methods, conclusions, and changes in bilirubin levels regarding PD