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Indeed, genes reported to be regulated by known PXR ligands are CYP1A1, CYP2C8, CYP2C9, MDR1, MRP2, and members of the UGT, sulfotransferase, and carboxylesterase families (Goodwin, Redinbo, and Kliewer, 2002)

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Conversely, optogenetic activation of DMV-projecting PVN Glu neurons led to significantly increased fecal output and fecal water content, as well as faster motility and small intestinal transit rates in ChR2-expressing mice compared to mCherry-expressing controls (Fig