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Despite compelling preclinical evidence, clinical translation of Nrf2 activators for MIRI remains in its infancy, with a significant lack of published trial data specifically in this acute setting (summarized in Table 1)

The MAPK/ERK axis runs in parallel

3.2 Kidney Fish kidneys are essential for regulating ions and water balance in freshwater (FW) ( Figure 1A ) and seawater (SW) ( Figure 1B ) environments

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