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B12 also plays a significant role in preventing vascular and cognitive diseases through its involvement in the conversion of homocysteine to methionine and then to Sadenosylmethionine

doi: 10.1016/j.biochi.2013.08.022

In the physiological environment, IECs secrete EVs from the apical or basolateral surfaces, and these EVs contain immunomodulatory molecules expressed on their surface, such as major histocompatibility complex (MHC)-I, MHC-II, and human leukocyte antigen-DM (HLA-DM) (Mallegol et al., 2007)