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Hepatology (2013) 57:33950

doi: 10.3390/ijms19072084 252 XiaoL.ZhaoF

Serine-derived glycine together with cysteine and glutamate constitute the glutathione molecule, essential for the maintenance of the redox state allowing cellular metabolic functioning and chemoresistance

Catechol-O-methyltransferase (COMT)-mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics: Importance in pathophysiology and pathogenesis