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Venugopal & Jaiswal, 1998

Fan L, et al

The combination was well tolerated but had high toxicity, and the main adverse events included loss of appetite, nausea, and fatigue ( Table 2 for more details)

Most of the tools currently used to study the permeability of nanocarriers to the BBB, drug quantification, and their safety and efficacy assays are indirect or destructive

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