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However, repeated administration of GHRP has been reported to desensitize its stimulatory effect on GH secretion, and there have been no studies of the growth promoting effect after its long-term use, thereby limiting clinical application.21 In our study, oral administration of 4 mg/kg of MK-677 increased the peak concentrations of serum GH by 1.8-fold, compared to basal levels, and GH AUC was significantly increased, suggesting that oral administration of MK-677 has GH-releasing activity