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Counts per gene were calculated using custom scripts acting in a HTSeqcount compatible mode with the following parameters: --format=bam --minaqual=10 --stranded=reverse mode=union (51, 52)

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Disruptions in SNX1 and the core retromer component VPS29 impair formation of the spherical vesicles near MVBs, lead to the development of enlarged MVBs, and result in embryonic lethality before the globular stage