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S1C, clusters 1, 3, and 19 represent TECs and enriched pathways of Metabolism pathways, Glyoxylate and dicarboxylate metabolism, PPAR signaling, and other pathways during the injury, which provided us with hints for subsequent studies

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For example, combining Mn with YM101 can reshape tumours from immune-excluded/suppressed states to inflammatory states, effectively controlling tumour growth and prolonging survival in tumour-bearing mice (31)

Furthermore, we noted downregulation of astrocytic markers including AQP4, S100B, FABP7 and F3 after 1-day treatment and CST3, HOPX, SPARC , CLU after the 3-day treatment (Fig