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prescriptions that exceed 100 mg are subject to scrutiny for opioid abuse [16]

Kudo et al., 2012

The lysine residue's positive charge facilitates interaction with glycosaminoglycans and negatively charged phospholipids in cellular membranes, enhancing uptake efficiency

MMP regulation

Furthermore, since most studies on cosmetically relevant PDEVs have been conducted in animal models, their clinical efficacy may differ in humans due to interspecies variations in skin biology