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It is possible to speculate that GST and S-crystallin may be evolved from a common GST ancestor under the same evolutionary pressure, i.e

We wondered whether the longevity upon -ketoglutarate supplementation would be mediated through its co-factor activity for prolyl-hydroxylase

2I), which are two essential components of glutamate-cysteine ligase (GCL) involved in GSH synthesis, suggesting a compensatory mechanism under mitochondrial GSH deprivation

In addition, assessment of IVD structural changes with x-ray and MRI will be investigated, as well as the use of pain-relieving medications and variations of the patients' occupational status

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