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Moreover, a minor proportion of this agent can be metabolized within the liver by the cytochrome P450 enzymes (primarily by CYP2E1) to NAPQI, which is detoxified by conjugation and excreted in the glutathione or NAC forms ( Figure 2 )

34 Acteoside isolated from Cirsium setosum was also reported to exhibit moderate hepatoprotective activities against D -GalNinduced HL-7702 cell damage at a concentration of 10 M

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D., Gallagher M., Jneid H., Garcia S., Cass A., Thwin S.-S., et al

2, 3) which is the nodal point for both inflammatory and growth factor communication