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However, it is important to note that the enrichment of predicted targets among enzymes known to interact with viruses is still significant when removing enzymes of the respiratory chain and TCA cycle (Fishers exact test p = 9.3 10 4 , odds ratio 1.32.6)

Extracellular superoxide dismutase (EC-SOD, SOD3) is the major extracellular SOD found predominantly in the extracellular matrix of tissues

Larger, more definitive Phase 3 trials are anticipated to clarify its efficacy

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Furthermore, DNA methylation, such as that observed in the ALOX12 and TP53 genes, may also serve as a link between ferroptosis and IS (Fig