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111 Additionally, the permanent nature of DNA editing raises safety concerns, particularly if targeting genes with pleiotropic effects or those that lack pharmacologic or human genetic validation

Stable sh-knockdown sequences used in this study

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Sciatic nerve images were obtained using a x10 objective of Zeiss LSM780 confocal microscope and montaged using Photoshop (Adobe)

DISCUSSION 3 The most common presentation of alopecia areata is the development of isolated non-cicatricial alopecic patches involving the occipital or parietal scalp with the presentation of alopecia totalis and universalis being less common