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Vitamin B12 is central to red blood cell formation, neurological function, and energy production

J Transl Med 14 , 3 (2016)

Moreover, myofibroblast activation and the development of multiple organ fibrosis are substantially attenuated in CD38-null mice with elevated NAD + 24

it also found increasing memory impairment as B12 levels dropped even whilst within currently defined acceptable ranges and that B12 interventions are effective once levels are less than 300 pmol/L