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(c) the National Institute on Deafness and Other Communication Disorders (NIDCD) at NIH, under award number T32DC005360 (ZF)

The body produces it, and levels decline with age

This adaptation presents a targetable vulnerability whereby the functional inhibition of this adaptive response greatly increased the effectiveness of 5FU across CRC models in vitro and in vivo

Spinocerebellar ataxias (SCAs) represent a genetically heterogeneous subset of autosomal dominant progressive neurological disorders predominantly caused by expansion of a glutamine-encoding CAG trinucleotide repeat, leading to the accumulation of misfolded proteins, dysfunction of ion channels and mitochondria, and ultimately neurodegeneration, with PCs, brainstem, and spinal cord neurons being particularly affected in SCA type 1 (Watase et al., 2002