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In hPS cell-based cell therapy in PD, CRISPR engineering enables enriched survival (in vivo screen), homogeneous (the reporter-based enrichment), safer (inducible fail-safes), controllable (chemogenetic control), immune-adapted (hypo-immunogenic edits) and pathology-resistant ( SNCA downtitration and GBA1 upregulation) to overcome acute cell death, contamination, graft rejection and long-term prevention of -syn propagation in grafts

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J., Vieth, R., Umhau, J