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Pathway enrichment analysis revealed the prolactin (PRL) signaling pathway as crucial in esculetin's action against UC, supported by strong molecular docking affinity to PRL and its receptor

In this review, we intended to describe how cytokine storm is associated with the severity of COVID-19 disease and also tried to find out the best possible way to manage the hyperinflammatory response due to cytokine storm during COVID-19 infection using several interleukin receptor antagonists, inhibitors, intravenous immunoglobulins, cytokine adsorption device and repurposing of pre-existing antiviral and some antimalarial drugs etc