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doi: 10.1007/s12975-017-0559-x 146 Tokuyama-TodaRUmekiHOkuboMTerada-ItoCYudoTIdeSet al

J.PosaL.Ochoa-SanchezR.EnnsJ.Lopez-CanulM.et al (2019)

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The green surfaces (I and II) indicate flexible loop regions that were not visible in the LmTryS crystal structure (pdb:2vps): In the EcGspS structure (A) region I (Gly 242 to Pro 249) does not offer any additional binding site near the spermidine moiety of the Gsp analogue, while in the LmTryS model (B) the corresponding loop (Gly250 to 262

It activates the tyrosine kinase activity of IGF-1 receptor (IGF-1R), induces downstream MAPK/ERK and PI3K/Akt pathways, promotes the expression of cell cycle proteins (Cyclin D1, E), and accelerates the transition of cells from G1 phase to Sphase