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ER and mitochondria are two pivotal organelles involved in the function and survival of -cells ( In vivo and in vitro studies have highlighted distinct or combined role of ER stress and mitochondria dysfunction in -cell functionality ( Figure 2 As highlighted in previous sections, transcriptome studies on both human and mouse islets and -cells, as well as polygenic and monogenic forms of DM have provided compelling evidence on the importance of ER stress and UPR in -cell dysfunction and diabetes

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Front Oncol (2020) 10:596197