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Neuropathic pain 2021

Yi C, Pan X, Yan H, Guo M, Pierpaoli W

Off-label use in non-HIV populations relies on extrapolation, not large RCTs

Inflammation, oxidative stress, senescence in atherosclerosis: thioredoxine-1 as an emerging therapeutic target

58 Respiratory Syncytial Virus In in vitro modeling of RSV infection carried out in cultures of primary normal human bronchial epithelial cells, N-acetylcysteine significantly inhibited viral infection, re-established the number of beating cells, restored the virus-induced decrease in expression of -tubulin and genes involved in ciliagenesis such as DNAI2 and FOXJ1, inhibited IL-13, MUC5AC, and GOB5 upregulation, inhibited ICAM1 expression, increased heme-oxygenase 1 expression which correlated with the restoration of cellular antioxidant capacity, and enhanced intracellular hydrogen peroxide and glutathione concentrations