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The greatest increase in inhibition was observed in the first 10 min: colostrum 1 demonstrated 13.5%, 35.0%, and 51.8% inhibition at concentrations of 0.25 mg/mL, 0.5 mg/mL, and 0.75 mg/mL, respectively, while 2 demonstrated 15.1%, 40.1%, and 61.2% inhibition

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Your risk markedly increases with concurrent substance abuse, particularly CNS depressants