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IRE1 has Cys residues indispensable for signaling (Cys148 and Cys332), PDIA6 can direct binding in the luminal domine of IRE1 via a disulfide bond, also ROS can affect these Cys residues affecting the oligomerization of IRE1 consequently its activation (Eletto et al

Activity of the Dietary Antioxidant Ergothioneine in a Virus Gene-Based Assay for Inhibitors of HIV Transcription

Heres to making the most of it

When you swallow anything, it travels through the stomach, into the small intestine, gets absorbed into the portal vein, and flows directly to the liver before reaching systemic circulation

On the utility of pooling biological samples in microarray experiments