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The review also evaluates therapeutic strategies targeting NO, such as nitric oxide synthase inhibitors and NO delivery systems, while addressing challenges such as site-specific modulation and off-target effects

Gomisin A, for example, has been associated with reduced alanine aminotransferase and aspartate aminotransferase levels, activation of pregnane X receptors, and improved lipid metabolism, with emerging efficacy observed in preclinical models of non-alcoholic fatty liver disease (NAFLD)

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In addition to complex damaging glutamate excitotoxic mechanisms, excitotoxic glutamate inhibits mTOR signalling and causes elevated neuronal insulin resistance (Pomytkin et al

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