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Why Bro Science Persists Despite Contradictory Evidence Because it is: Simple Familiar Repeated Rarely challenged Most people do not read: Preclinical data Pharmacologic design rationale Human safety studies They repeat what they heard

But polyamine biosynthesis is a pathway that eats SAM

A mouse metabolises on a faster clock than a human, and a controlled diet in a cage is not a free-living human diet so even the week-numbers above should be read as the shape of a gradual response, not a promise that a human would see anything on the same calendar

Discomfort is minimal and resolves within seconds