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For managing symptoms of severe itching in patients with cholestatic DILI, antihistamines like hydroxyzine or diphenhydramine, or bile acid resins like cholestyramine, can be helpful

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

CSCs exhibit a resistance to radiation and chemotherapy due to the upregulation of numerous detoxifying enzymes, such as superoxide dismutase 2, glutathione peroxidases and heme oxygenase 1, that increase drug efflux and DNA repair capabilities (44,67,68)

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Organochlorine chemicals, such as DDT and dioxin, are generally difficult to metabolize due to the large amount of unconjugated chlorine atoms in their structure