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The findings provide valuable insights to optimize metformins therapeutic application in PCOS treatment, enabling safer pharmacologic management and improved patient prognoses

Notably, no studies to date have specifically tested this hypothesis in patients with Hashimotos thyroiditis, limiting the generalisability of existing evidence to this particular population

therefore, a full PK study design was selected

Two-tailed t-tests followed by Benjamini-Hochberg FDR testing was performed comparing HT-1080 N Control to EMP2 KO cells, with an FDR cutoff of q 0.05)

The neurological phenotype of FRDA includes cerebellar atrophy in the dentate nucleus, the dorsal root ganglia become smaller, reduction in the spinal cord diameter, and loss of corticospinal and spinocerebellar tracts (Koeppen, 2011