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The context of pathway activation matters enormously

Tapering may be helpful if using long term (6+ weeks), but isnt physiologically necessary

Maintenance Approach Your provider will recommend an appropriate maintenance schedule to help sustain results after your initial treatment protocol is complete.

The widely repeated claim that Dihexa is "seven orders of magnitude more potent than BDNF" traces to McCoy 2013 (PMID 23055539), the paper now under an Expression of Concern