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Unknown impacts on the target protein The insertion of protein tags (especially larger tags) may have unknown impacts on the structural and functional characteristics of the target protein

Morever, specific gut bacteria were associated with disease activity of AS patients

The toxicity of intramuscularly administered rotigotine behenate-loaded PLGA microspheres (rotigotine loading of 22.527%) was evaluated over a 20-week period in Sprague Dawley (107 males and 107 females) rats which received 5 doses of rotigotine behenate-loaded PLGA every 28 days at different doses 60, 180, and 540 mg/kg (calculated as rotigotine) 137

exploited the ability of quantum dots to traverse cartilage and access SB