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The intraperitoneal administration of cannabinoids results in increased plasma ghrelin levels and stomach ghrelin expression in rats (412) and CB1 receptor antagonism with rimonabant reduces ghrelin levels (413), suggesting that the orexigenic effects of cannabinoids may also be connected to an increase in ghrelin secretion from the gastric X/A-like cells

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Interestingly, the early (3.5 days) slight (0.5-fold more than controls, while the peak was 7-fold) but significant increase in Enpp6 -positive newly-forming/formed OLs was accompanied by a concomitant and very comparable degree of decrease (52%) in Pdgfra -positive OPCs, with the specific values of 50 per mm 2 increase for Ennp6 -positive cells, and 80 per mm 2 decrease for Pdgfra -positive cells

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CC did further literature review and wrote the initial draft of the manuscript