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"Effects of extracellular matrix-degrading proteases matrix metalloproteinases 3 and 9 on spatial learning and synaptic plasticity." J Neurochem 96(5): 1227-41

Thus, undergoing trials specifically evaluating the effect of roxadustat on kidney disease progression may be warranted

Animal studies show substantial evidence across stroke models (full functional recovery in spatial memory, motor coordination, balance), Parkinsons models (protection of dopaminergic neurons, near-complete prevention of mortality), multiple sclerosis models (significantly less brain damage), and traumatic brain injury (reduced hemorrhage and edema)