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Indeed, we have previously demonstrated that the CD44 gene promoter is de-methylated following irradiation, resulting in over-expression and presentation of this highly adhesive protein on the apical membrane of endothelial cells, increasing the risk of atherosclerotic plaque development 18

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Together with the fact that no clear hints for the need for rescue analgesia could be drawn from the data of the von Frey Filament tests, it is questionable whether the use of a test for skin hyperesthesia is a good choice for evaluating immediate postoperative analgesia

All participants gave written informed consent to participate in the experiment