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Common signs of B12 deficiency include: Fatigue or low energy Brain fog or memory issues Numbness or tingling in hands and feet Mood changes, anxiety, or depression Poor concentration Blood tests can help assess deficiency

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Intrinsic factor production can be impaired by aging, autoimmune conditions (pernicious anemia), gastric surgery, atrophic gastritis, and long-term use of proton pump inhibitors or H2 blockers